In vivo inhibitory effect of anti-muscarinic autoantibodies on the parasympathetic function in Chagas disease.
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چکیده
[1] Shave RE, Whyte GP, George K, Gaze DC, Collinson PO. Prolonged exercise should be considered alongside typical symptoms of acute myocardial infarction when evaluating increases in cardiac troponin T. Heart 2005;91:1219–20. [2] Middleton N, George K, Whyte G, Gaze D, Collinson P, Shave R. Cardiac troponin T release is stimulated by endurance exercise in healthy humans. J Am Coll Cardiol 2008;52:1813–4. [3] Scharhag J, Herrmann M, Urhausen A, Haschke M, Herrmann W, Kindermann W. Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 2005;150:1128–34. [4] Collinson PO, Stubbs PJ, Kessler AC.Multicentre evaluation of the diagnostic value of cardiac troponin T, CK-MB mass, and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice. Heart 2003;89:280–6. [5] http://www.census.gov/compendia/statab/cats/arts_recreation_travel/recreation_and_leisure_activities.html. Downloaded 13th January 2009. [6] Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868–77. [7] Wu AH, Fukushima N, Puskas R, Todd J, Goix P. Development and preliminary clinical validation of a high sensitivity assay for cardiac troponin using a capillary flow (single molecule) fluorescence detector. Clin Chem 2006;52:2157–9. [8] Coats AJ. Ethical authorship and publishing. Int J Cardiol 2009;131:149–50.
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عنوان ژورنال:
- International journal of cardiology
دوره 145 2 شماره
صفحات -
تاریخ انتشار 2010